PM449. Hot genes in schizophrenia: case-control, pharmacogenetics and exploratory analyses in two independent samples

s | 63 palate. In this study, we investigated the association between coding region single nucleotide polymorphisms (cSNPs) of ADAMATS20 gene and schizophrenia in a Korean population. Methods: Six cSNPs (rs10506226, rs10880473, rs7310011, rs7297737, rs7302446 and rs11182088) in 276 schizophrenia patients and 406 control subjects were genotyped using Sequenom iPLEX-Gold assay. The associations of SNPs were analyzed based on logistic regression using multiple inheritance models (log-additive, dominant and recessive models). Results: In our study, significant associations between rs7302446, rs7297737 and rs7310011 and schizophrenia were shown in the dominant models (p = 0.0057, OR = 1.72, 95% CI = 1.17–2.52 for rs7302446; p = 0.0043, OR = 1.75, 95% CI = 1.19–2.58 for rs7297737; p = 0.006, OR = 1.71, 95% CI = 1.17–2.52 for rs7310011). We also found a significant association between rs11182088 and schizophrenia in the log-additive (p = 0.004, OR = 1.44, 95% CI = 1.12–1.85) and dominant models (p = 0.048, OR = 1.57, 95% CI = 1.15–2.16). Additionally, in the analysis of haplotypes, the ATGCTG, ATGCTA and CCATAA haplotypes consisting six cSNPs were associated with schizophrenia (p = 0.0006, 0.044, and 0.020, respectively). Conclusion: These results suggest that the ADAMTS20 gene contributes to the susceptibility of schizophrenia. PM448 Investigation of maternal effects, maternal-fetal interactions and parent-of-origin effects (imprinting), using mothers and their offspring with schizophrenia Byung Dae Lee, Hee Jeong Jeong, Young Min Lee, Eunsoo Moon, Je Min